Brown and colleagues at Weill Cornell Medical University and the University of Michigan, synthesized the newest studies on anesthesia, coma and sleep to theorize how anesthesia works in the brain. They hope their study will aid doctors to find new ways to bring sufferers out of comas, especially if they can mimic the orderly return to consciousness from the chemically induced coma of anesthesia. Consciousness is a very dynamic process, said co-author Dr. Nicholas D. Schiff in a statement. And now we have a great way of studying it. The study was backed by National Institutes of Wellness grants as well as a National Institutes of Wellness Director’s Pioneer Award, and by grants from the James S.Lead author Dr. Kevin Bruen says the preservation of limbs, which maximizes patient practical outcome, is perhaps the greatest benefit conferred by the use of tpa in frostbite damage. The drug is not appropriate for all frostbite victims as much have other accidental injuries involving inner bleeding, which will be worsened by the drug. Cochran says bleeding is the biggest concern and that does to some extent limit the use of tpa. Dr. Cochran says more studies at different centers are had a need to confirm the results and to determine if the drug would work differently in patients exposed to extreme chilly all at one time – – allowing for no intermittent intervals of thawing – – weighed against those whose accidental injuries were the result of repeated freezing and thawing in much less extreme temperatures.