Related StoriesMD Anderson study reveals why chemotherapy medications not effective for many pancreatic cancer patientsNew findings reveal association between colorectal malignancy and melanoma drug treatmentOvarian cancer sufferers with a history of oral contraceptive make use of have better outcomesPutting their work in context, the investigators wrote, Selective blockade of gene expression by designed small molecules is a simple challenge at the interface of chemistry, biology, and medicine. Transcription factors have been being among the most elusive targets in genetics and drug discovery, but the fields of chemical biology and genetics have evolved to a spot where this task could be addressed.These investigations can allow us to better understand at a molecular level how blood cells fail in individual patients-and to check and generate innovative treatments for the patients' illnesses. Weiss, with Monica Bessler, M.D., Philip Mason, Ph.D., and Deborah L. French, Ph.D., all of CHOP, led a study on iPSCs and Diamond Blackfan anemia published on-line June 6 in Bloodstream. Another scholarly research by Weiss, French and colleagues in the same journal on April 25 centered on iPSCs in juvenile myelomonocytic leukemia . In DBA, a mutation helps prevent a patient's bone marrow from producing normal quantities of red blood cells, leading to severe, life-threatening anemia sometimes.