The principal outcome measure for every study is differ from dual blind baseline for TC-5214 on the Montgomery-Asberg Depression Rating Level when compared with placebo.. AstraZeneca, Targacept commence enrollment in TC-5214 Stage 3 clinical advancement for MDD Targacept and AstraZeneca, Inc., today announced the enrollment of the first individual in the Phase 3 clinical development system for TC-5214, a nicotinic channel blocker.The ligaments and tendons that produce the finger work, can be easily damaged. These parts of the finger are extremely susceptible to tears, especially when crimping. If you feet slips or your bodyweight shifts in just the wrong manner, your fingers will end up being bearing the complete weight of your body, which is not desirable. Prevention may be the greatest weapon against the severe setbacks of climbing. Recovery can be lengthy, as the individual gradually works back up to full power.